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In a phase IIb trial, 91 patients with active UC (defined as full Mayo score ≥5, rectal bleeding score ≥1, endoscopy sub-score ≥2) were randomized to bi-weekly IV olamkicept 600 mg, 300 mg or placebo.66 The primary endpoint of clinical response at week 12 was noted in 58.6% vs 34.5% in the olamkicept 600 mg vs placebo (p = 0.03)